TED英語(yǔ)演講：長(zhǎng)生不老的細(xì)胞科學(xué)
是什么讓我們的身體老化、皮膚長(zhǎng)出皺紋、頭發(fā)轉(zhuǎn)成白色、免疫系統(tǒng)變?nèi)?生物學(xué)家伊麗莎白布萊克班恩對(duì)于這個(gè)問(wèn)題所做的研究，與同儕共同贏得了諾貝爾獎(jiǎng)。該研究發(fā)現(xiàn)了酶，這種酶會(huì)補(bǔ)充染色體末端的套子(端粒)，這個(gè)套子會(huì)在細(xì)胞分裂時(shí)磨損。下面是小編為大家收集關(guān)于TED英語(yǔ)演講：長(zhǎng)生不老的細(xì)胞科學(xué)，歡迎借鑒參考。
TED演講：長(zhǎng)生不老的細(xì)胞科學(xué)
Where does the end begin?Well, for me, it all began with this little fellow.This adorable organism --well, I think it’s adorable --is called Tetrahymena and it’s a single-celled creature.It’s also been known as pond scum.So that’s right, my career started with pond scum.
結(jié)束是從何開(kāi)始的?對(duì)我來(lái)說(shuō)，它開(kāi)始于這個(gè)小家伙。這可愛(ài)的有機(jī)體，我認(rèn)為它很可愛(ài)，它叫做四膜蟲(chóng)，是種單細(xì)胞生物。它也就是池塘浮渣。是的，我的職涯始于池塘浮渣。
Now, it was no surprise I became a scientist.Growing up far away from here,as a little girl I was deadly curiousabout everything alive.I used to pick up lethally poisonous stinging jellyfish and sing to them.And so starting my career,I was deadly curious about fundamental mysteriesof the most basic building blocks of life,and I was fortunate to live in a society where that curiosity was valued.
我變成科學(xué)家并不讓人意外。我在離這里很遠(yuǎn)的地方長(zhǎng)大，我小時(shí)候非常有好奇心，對(duì)所有的生物都好奇。我以前會(huì)撿起有致命劇毒會(huì)螫人的水母，然后對(duì)牠們唱歌。所以，開(kāi)始我的職涯時(shí)，我非常好奇，想解開(kāi)最根本的謎題，想知道構(gòu)成生命的基礎(chǔ)積木是什么，很幸運(yùn)，我所在的社會(huì)很重視好奇心。
Now, for me, this little pond scum critter Tetrahymenawas a great way to study the fundamental mysteryI was most curious about:those bundles of DNA in our cells called chromosomes.And it was because I was curious about the very ends of chromosomes,known as telomeres.Now, when I started my quest,all we knew was that they helped protect the ends of chromosomes.It was important when cells divide.It was really important,but I wanted to find out what telomeres consisted of,and for that, I needed a lot of them.And it so happens that cute little Tetrahymenahas a lot of short linear chromosomes,around 20,000,so lots of telomeres.And I discovered that telomeres consisted of special segmentsof noncoding DNA right at the very ends of chromosomes.
對(duì)我而言，四膜蟲(chóng)這池塘浮渣小生物是研究我最好奇的根本謎題的好方式：我們的細(xì)胞內(nèi)大量的 DNA，也就是所謂的染色體。因?yàn)槲覍?duì)染色體的末端很好奇，也就是所謂的端粒。當(dāng)我開(kāi)始探索，我們只知道：它們協(xié)助保護(hù)染色體的末端。細(xì)胞分裂時(shí)，這點(diǎn)很重要。它相當(dāng)重要，但我想要了解端粒是什么組成的，為這個(gè)目的，我需要很多端粒。剛好這個(gè)可愛(ài)的小四膜蟲(chóng)有很多短短線(xiàn)性的染色體。大約兩萬(wàn)個(gè)，所以會(huì)有很多端粒。我發(fā)現(xiàn)端粒包括位在染色體最末端未編碼的特殊 DNA 區(qū)段。
But here’s a problem.Now, we all start life as a single cell.It multiples to two.Two becomes four. Four becomes eight,and on and on to form the 200 million billion cellsthat make up our adult body.And some of those cells have to divide thousands of times.In fact, even as I stand here before you,all throughout my body, cells are furiously replenishingto, well, keep me standing here before you.So every time a cell divides, all of its DNA has to be copied,all of the coding DNA inside of those chromosomes,because that carries the vital operating instructionsthat keep our cells in good working order,so my heart cells can keep a steady beat,which I assure you they’re not doing right now,and my immune cellscan fight off bacteria and viruses,and our brain cells can save the memory of our first kissand keep on learning throughout life.
但，有一個(gè)問(wèn)題。生命是從單細(xì)胞開(kāi)始的。一個(gè)會(huì)變成兩個(gè)，兩個(gè)變成四個(gè)，四個(gè)變成八個(gè)，一路這樣下去，形成了二十萬(wàn)兆個(gè)細(xì)胞，組成了成人的身體。有些細(xì)胞需要分裂數(shù)千次。事實(shí)上，即使我站在各位面前，我整個(gè)身體的細(xì)胞正瘋狂地補(bǔ)充，讓我能夠持續(xù)站在你們面前。每當(dāng)一個(gè)細(xì)胞分裂，它所有的 DNA 都會(huì)被復(fù)制，那些染色體中所有編碼的 DNA，因?yàn)槟菐в袠O重要的運(yùn)作指示，讓我們的細(xì)胞能處于良好的工作狀態(tài)，這么一來(lái)我的心臟細(xì)胞才能保持穩(wěn)定的心跳，我向各位保證，它們現(xiàn)在并沒(méi)做到，而我的免疫細(xì)胞，能擊退細(xì)菌和病毒，我們的頭腦細(xì)胞能儲(chǔ)存我們初吻的記憶，并在整個(gè)人生中持續(xù)學(xué)習(xí)。
But there is a glitch in the way DNA is copied.It is just one of those facts of life.Every time the cell divides and the DNA is copied,some of that DNA from the ends gets worn down and shortened,some of that telomere DNA.And think about itlike the protective caps at the ends of your shoelace.And those keep the shoelace, or the chromosome, from fraying,and when that tip gets too short, it falls off,and that worn down telomere sends a signal to the cells.The DNA is no longer being protected.It sends a signal. Time to die.So, end of story.
但復(fù)制 DNA 的方式有個(gè)小毛病，僅是生命的事實(shí)之一。每當(dāng)細(xì)胞分裂、DNA 被復(fù)制，某些末端 DNA 會(huì)磨損縮短，一些端粒的 DNA?？梢杂眠@方式來(lái)想：就像你的鞋帶末端的保護(hù)套。它們能讓鞋帶或染色體不會(huì)被磨損，當(dāng)尖端變得太短時(shí)，它就會(huì)脫落，而那被磨損掉的端粒就會(huì)發(fā)送一個(gè)訊號(hào)給細(xì)胞?！高@ DNA 不再受到保護(hù)?！顾l(fā)出訊號(hào)。是死亡的時(shí)候了。所以，故事結(jié)束。
Well, sorry, not so fast.It can’t be the end of the story,because life hasn’t died off the face of the earth.So I was curious:if such wear and tear is inevitable,how on earth does Mother Nature make surewe can keep our chromosomes intact?
抱歉，沒(méi)那么快。故事不可能這樣結(jié)束，因?yàn)樯€沒(méi)從地球表面上消逝。所以我很好奇：如果這種損耗是無(wú)可避免的，大自然到底要如何確保我們能保持不讓染色體受損?
Now, remember that little pond scum critter Tetrahymena?The craziest thing was,Tetrahymena cells never got old and died.Their telomeres weren’t shortening as time marched on.Sometimes they even got longer.Something else was at work,and believe me, that something was not in any textbook.So working in my lab with my extraordinary student Carol Greider --and Carol and I shared the Nobel Prize for this work --we began running experimentsand we discovered cells do have something else.It was a previously undreamed-of enzymethat could replenish,make longer, telomeres,and we named it telomerase.And when we removed our pond scum’s telomerase,their telomeres ran down and they died.So it was thanks to their plentiful telomerasethat our pond scum critters never got old.
還記得那池塘浮渣小生物四膜蟲(chóng)嗎?最瘋狂的是，四膜蟲(chóng)細(xì)胞從來(lái)不會(huì)變老或死亡。牠們的端粒并不會(huì)隨時(shí)間而變短。有時(shí)甚至還會(huì)變長(zhǎng)。還有某樣?xùn)|西在運(yùn)作，相信我，那某樣?xùn)|西并不在任何教科書(shū)中。所以，我和杰出學(xué)生凱洛葛萊德在實(shí)驗(yàn)室中合作──凱洛和我共享這項(xiàng)研究贏得的諾貝爾獎(jiǎng)──我們開(kāi)始進(jìn)行實(shí)驗(yàn)，我們發(fā)現(xiàn)細(xì)胞的確有其他的東西。是先前意想不到的酶(酵素)，它能補(bǔ)充端粒，讓端粒更長(zhǎng)，我們將它命名為「端粒酶」。當(dāng)我們移除池塘浮渣的端粒酶后，牠們的端粒就會(huì)耗盡而死亡。所以要?dú)w功于豐富的端粒酶，我們的池塘浮渣才能永生不老。
OK, now, that’s an incredibly hopeful messagefor us humans to be receiving from pond scum,because it turns outthat as we humans age, our telomeres do shorten,and remarkably,that shortening is aging us.Generally speaking,the longer your telomeres,the better off you are.It’s the overshortening of telomeresthat leads us to feel and see signs of aging.My skin cells start to dieand I start to see fine lines, wrinkles.Hair pigment cells die.You start to see gray.Immune system cells die.You increase your risks of getting sick.In fact, the cumulative research from the last 20 yearshas made clear that telomere attritionis contributing to our risks of getting cardiovascular diseases,Alzheimer’s, some cancers and diabetes,the very conditions many of us die of.
那是我們?nèi)祟?lèi)能從池塘浮渣身上得到的一個(gè)非常有希望的訊息，因?yàn)榻Y(jié)果發(fā)現(xiàn)，隨著我們?nèi)祟?lèi)年紀(jì)增長(zhǎng)，我們的端粒確實(shí)會(huì)變短，很驚人的是，那縮短現(xiàn)象讓我們變老。一般來(lái)說(shuō)，你的端粒越長(zhǎng)，你的狀況就會(huì)越好。是端粒過(guò)度減短的現(xiàn)象導(dǎo)致我們會(huì)感到及看到老化的征象。我的皮膚細(xì)胞開(kāi)始死亡，我就會(huì)開(kāi)始看到線(xiàn)條、皺紋。頭發(fā)色素細(xì)胞死亡，你就會(huì)開(kāi)始看到白發(fā)。免疫細(xì)胞死亡，你被攻擊的風(fēng)險(xiǎn)就會(huì)提升。事實(shí)上，過(guò)去二十年所累積的研究清楚地指出，端粒損耗可能造成罹患像是：心血管疾病、阿滋海默癥、某些癌癥，以及糖尿病等許多致死疾病的風(fēng)險(xiǎn)。
And so we have to think about this.What is going on?This attrition,we look and we feel older, yeah.Our telomeres are losing the war of attrition faster.And those of us who feel youthful longer,it turns out our telomeres are staying longerfor longer periods of time,extending our feelings of youthfulnessand reducing the risks of all we most dreadas the birthdays go by.
所以我們得要想想這一點(diǎn)。發(fā)生了什么事?這種損耗，我們看起來(lái)且感覺(jué)起來(lái)變老了。我們的端粒在損耗之戰(zhàn)中敗退得很快。至于覺(jué)得年輕時(shí)間比較長(zhǎng)的人，結(jié)果發(fā)現(xiàn)是端粒能留比較久，比較長(zhǎng)的時(shí)間，延長(zhǎng)我們對(duì)于年輕的感覺(jué)，并減少我們隨著每個(gè)生日過(guò)去而最害怕的那些風(fēng)險(xiǎn)。
OK,seems like a no-brainer.Now, if my telomeres are connectedto how quickly I’m going to feel and get old,if my telomeres can be renewed by my telomerase,then all I have to do to reverse the signs and symptoms of agingis figure out where to buy that Costco-sized bottleof grade A organic fair trade telomerase, right?Great! Problem solved.
好。似乎很簡(jiǎn)單。如果我的端粒和我多快感到變老及實(shí)際變老是有關(guān)聯(lián)的，如果我能用端粒酶來(lái)復(fù)原端粒，那么若我想要反轉(zhuǎn)老化的征兆和癥狀，就是要找個(gè)地方買(mǎi)像好市多那樣超大罐、A 級(jí)、有機(jī)、公平貿(mào)易的端粒酶，對(duì)吧?好極了!問(wèn)題解決。
(Applause)
(掌聲)
Not so fast, I’m sorry.Alas, that’s not the case.OK. And why?It’s because human genetics has taught usthat when it comes to our telomerase,we humans live on a knife edge.OK, simply put,yes, nudging up telomerase does decrease the risks of some diseases,but it also increases the risks of certain and rather nasty cancers.So even if you could buy that Costco-sized bottle of telomerase,and there are many websites marketing such dubious products,the problem is you could nudge up your risks of cancers.And we don’t want that.
很抱歉，沒(méi)那么快。唉，并不是那樣的。那為什么呢?因?yàn)槿祟?lèi)遺傳學(xué)教導(dǎo)我們，談到我們的端粒酶時(shí)，我們?nèi)祟?lèi)是住在刀緣上的。簡(jiǎn)單來(lái)說(shuō)，是的，增加端粒酶的確可以減少一些疾病的風(fēng)險(xiǎn)，但同時(shí)也會(huì)增加某些很糟糕的癌癥的風(fēng)險(xiǎn)。所以，就算你能買(mǎi)到像好市多那樣超大罐的端粒酶，有許多網(wǎng)站在行銷(xiāo)這類(lèi)可疑的產(chǎn)品，問(wèn)題是你有可能增加罹癌的風(fēng)險(xiǎn)。我們不想要那樣。
Now, don’t worry,and because, while I think it’s kind of funny that right now,you know, many of us may be thinking,well, I’d rather be like pond scum.
別擔(dān)心，因?yàn)?，雖然我覺(jué)得有點(diǎn)好笑，也許此刻很多人正想著，我寧可像池塘浮渣一樣。
(Laughter)
(笑聲)
There is something for us humansin the story of telomeres and their maintenance.But I want to get one thing clear.It isn’t about enormously extending human lifespanor immortality.It’s about health span.Now, health span is the number of years of your lifewhen you’re free of disease,you’re healthy, you’re productive,you’re zestfully enjoying life.Disease span, the opposite of health span,is the time of your life spent feeling old and sick and dying.So the real question becomes,OK, if I can’t guzzle telomerase,do I have control over my telomeres’ lengthand hence my well-being, my health,without those downsides of cancer risks?OK?
在這關(guān)于端粒以及維護(hù)端粒的真相中還是有我們?nèi)祟?lèi)可以學(xué)習(xí)之處。但我想先澄清一件事。重點(diǎn)并不是將人類(lèi)壽命期間延長(zhǎng)很多或是永生不死。重點(diǎn)是「健康期間」。健康期間，就是你人生中有多少年是沒(méi)有疾病、很健康、有生產(chǎn)力、能夠熱情享受人生的。相對(duì)于健康期間的「疾病期間」，指的就是你人生中有多長(zhǎng)時(shí)間覺(jué)得自己老、病、和垂死。所以，真正的問(wèn)題變成是，如果我無(wú)法狂飲端粒酶，我是否能控制端粒酶的長(zhǎng)度，進(jìn)而控制我的福祉、我的健康，而沒(méi)有癌癥風(fēng)險(xiǎn)的壞處?好嗎?
So, it’s the year 2000.Now, I’ve been minutely scrutinizing little teeny tiny telomeresvery happily for many years,when into my lab walks a psychologist named Elissa Epel.Now, Elissa’s expertise is in the effects of severe, chronic psychological stresson our mind’s and our body’s health.And there she was standing in my lab,which ironically overlooked the entrance to a mortuary, and --
所以，那是 2000 年。多年來(lái)，我很快樂(lè)地、分分鐘鐘地持續(xù)仔細(xì)觀察著那些極微小的端粒，直到有一天，名叫伊莉莎埃佩爾的心理學(xué)家走入了我的實(shí)驗(yàn)室。伊莉莎的專(zhuān)長(zhǎng)在于嚴(yán)重慢性心理壓力對(duì)于我們身、心健康的影響。她出現(xiàn)在我的實(shí)驗(yàn)室，很諷刺的是從實(shí)驗(yàn)室可以眺望停尸間的入口，而且──
(Laughter)
(笑聲)
And she had a life-and-death question for me.What happens to telomeres in people who are chronically stressed?she asked me.You see, she’d been studying caregivers,and specifically mothers of children with a chronic condition,be it gut disorder,be it autism, you name it --a group obviously under enormous and prolonged psychological stress.I have to say, her questionchanged me profoundly.See, all this time I had been thinking of telomeresas those miniscule molecular structures that they are,and the genes that control telomeres.And when Elissa asked me about studying caregivers,I suddenly saw telomeres in a whole new light.I saw beyond the genes and the chromosomesinto the lives of the real people we were studying.And I’m a mom myself,and at that moment,I was struck by the image of these womendealing with a child with a conditionvery difficult to deal with,often without help.And such women, simply,often look worn down.So was it possible their telomeres were worn down as well?
她有個(gè)生死問(wèn)題要問(wèn)我?！赣新詨毫Φ娜?，他們的端粒會(huì)發(fā)生什么事?」她這樣問(wèn)我。她一直在研究照護(hù)者，特別慢性病孩童的母親，可能是腸病，可能是自閉癥，任何你想得到的──這個(gè)族群很顯然處在巨大且長(zhǎng)期的心理壓力之下。我不得不說(shuō)，她的問(wèn)題深深改變了我。一直以來(lái)，我從小分子結(jié)構(gòu)的角度來(lái)思考端粒和控制端粒的基因。當(dāng)伊莉莎問(wèn)我關(guān)于照護(hù)者的問(wèn)題時(shí)，我突然從全新的角度去看端粒。我超越了基因和染色體，看到我們所研究的真實(shí)人類(lèi)的生活。我自己也是個(gè)母親，在那一刻，我被這個(gè)影像震撼了：這些女子通?？恳患褐φ疹櫤⒆樱蟹浅ｋy處理的疾病的孩子，往往沒(méi)有幫手。這類(lèi)女子，很顯而易見(jiàn)，經(jīng)?？雌饋?lái)是耗盡了精力的模樣。有沒(méi)有可能她們的端粒也被損耗掉了呢?
So our collective curiosity went into overdrive.Elissa selected for our first study a group of such caregiving mothers,and we wanted to ask:What’s the length of their telomerescompared with the number of years that they have been caregivingfor their child with a chronic condition?So four years go byand the day comes when all the results are in,and Elissa looked down at our first scatterplotand literally gasped,because there was a pattern to the data,and it was the exact gradient that we most feared might exist.It was right there on the page.The longer, the more years that is,the mother had been in this caregiving situation,no matter her age,the shorter were her telomeres.And the more she perceivedher situation as being more stressful,the lower was her telomerase and the shorter were her telomeres.
我們共同的好奇心促使我們加倍努力。伊莉莎為我們的第一項(xiàng)研究選了一群照護(hù)母親，我們想要問(wèn)：她們的端粒長(zhǎng)度和她們照顧有慢性疾病孩童多少年有什么關(guān)聯(lián)?所以，經(jīng)過(guò)了四年，所有結(jié)果都進(jìn)來(lái)的那一天，伊莉莎看著我們的第一張資料散布圖，真的是倒抽了一口氣，因?yàn)橘Y料的確呈現(xiàn)出了模式，且正是我們最怕存在的斜線(xiàn)。就在那里，呈現(xiàn)在那一頁(yè)上。母親在照護(hù)情境中的時(shí)間越久、越多年，不論她幾歲，她的端粒都會(huì)比較短。而且，她若越是感受到她所處的情境有很大的壓力，她的端粒酶就會(huì)越少，她的端粒也就會(huì)越短。
So we had discovered something unheard of:the more chronic stress you are under,the shorter your telomeres,meaning the more likely you were to fall victim to an early disease spanand perhaps untimely death.Our findings meant that people’s life eventsand the way we respond to these eventscan change how you maintain your telomeres.So telomere length wasn’t just a matter of age counted in years.Elissa’s question to me,back when she first came to my lab, indeed had been a life-and-death question.
所以我們發(fā)現(xiàn)了以前沒(méi)聽(tīng)過(guò)的事：越是在長(zhǎng)期壓力之下，你的端粒就會(huì)越短，意味著，你越可能很早就罹患疾病，也可能最終會(huì)比較早死。我們的發(fā)現(xiàn)意味著，人一生經(jīng)歷的事件、以及我們對(duì)這些事件的因應(yīng)方式，能夠改變你的端粒的維護(hù)狀況。所以端粒長(zhǎng)度并不只是把年齡換算成年數(shù)。伊莉莎一開(kāi)始到我實(shí)驗(yàn)室問(wèn)的問(wèn)題，的確是個(gè)生死的問(wèn)題。
Now, luckily, hidden in that data there was hope.We noticed that some mothers,despite having been carefully caring for their children for many years,had been able to maintain their telomeres.So studying these women closely revealed that they were resilient to stress.Somehow they were able to experience their circumstancesnot as a threat day in and day outbut as a challenge,and this has led to a very important insight for all of us:we have control over the way we ageall the way down into our cells.
幸運(yùn)的是，在那些資料中也藏有希望。我們注意到，有些母親雖然多年來(lái)都一直很細(xì)心照顧她們的孩子，卻仍然能維持著她們的端粒。仔細(xì)研究這些女性，發(fā)現(xiàn)她們對(duì)壓力的恢復(fù)力很強(qiáng)。她們能夠以某種方式，不一天到晚視她們所經(jīng)歷的情況為威脅，而視為是挑戰(zhàn)，這就導(dǎo)出了對(duì)于我們所有人都非常重要的洞見(jiàn)：我們能夠控制我們老化的方式且一路控制到我們的細(xì)胞。
OK, now our initial curiosity became infectious.Thousands of scientists from different fieldsadded their expertise to telomere research,and the findings have poured in.It’s up to over 10,000 scientific papers and counting.So several studies rapidly confirmed our initial findingthat yes, chronic stress is bad for telomeres.And now many are revealingthat we have more control over this particular aging processthan any of us could ever have imagined.A few examples:a study from the University of California, Los Angelesof people who are caring for a relative with dementia, long-term,and looked at their caregiver’s telomere maintenance capacityand found that it was improvedby them practicing a form of meditationfor as little as 12 minutes a day for two months.Attitude matters.If you’re habitually a negative thinker,you typically see a stressful situation with a threat stress response,meaning if your boss wants to see you,you automatically think, "I’m about to be fired,"and your blood vessels constrict,and your level of the stress hormone cortisol creeps up,and then it stays up,and over time, that persistently high level of the cortisolactually damps down your telomerase.Not good for your telomeres.
我們一開(kāi)始的好奇心變成是有感染力的。數(shù)以千計(jì)來(lái)自不同領(lǐng)域的科學(xué)家把他們的專(zhuān)長(zhǎng)加到了端粒的研究當(dāng)中，大量的發(fā)現(xiàn)涌入。有超過(guò)一萬(wàn)份科學(xué)論文，且還在增加中。所以，有許多研究很快就確認(rèn)了我們最初的發(fā)現(xiàn)，是的，長(zhǎng)期壓力對(duì)于端粒有害?，F(xiàn)在，許多研究指出，我們對(duì)于這種老化的過(guò)程所能掌控的程度，遠(yuǎn)超過(guò)任何人過(guò)去的想像。舉幾個(gè)例子：洛杉磯加州大學(xué)的一篇研究，對(duì)象是關(guān)于長(zhǎng)期照顧失憶親戚的人，該研究探究了這些照護(hù)者的端粒維護(hù)能力，發(fā)現(xiàn)他們?nèi)绻B續(xù)兩個(gè)月每天進(jìn)形某種形式的冥想，即使只有短短十二分鐘，也能改善這項(xiàng)能力。態(tài)度很重要。如果你是個(gè)習(xí)慣性負(fù)面思考的人，你通常遇到有壓力的情境時(shí)會(huì)產(chǎn)生威脅性的壓力反應(yīng)，意思是說(shuō)，如果你的老板想見(jiàn)你，你自動(dòng)會(huì)想：「我要被開(kāi)除了?！鼓愕难軙?huì)收縮，你的壓力賀爾蒙皮質(zhì)醇會(huì)升高，且一直維持很高，隨著時(shí)間過(guò)去，一直持續(xù)很高的皮質(zhì)醇其實(shí)就會(huì)減弱你的端粒酶。這對(duì)你的端粒不好。
On the other hand,if you typically see something stressful as a challenge to be tackled,then blood flows to your heart and to your brain,and you experience a brief but energizing spike of cortisol.And thanks to that habitual "bring it on" attitude,your telomeres do just fine.So ...What is all of this telling us?Your telomeres do just fine.You really do have power to change what is happeningto your own telomeres.
另一方面，如果你通常視很有壓力的事情為要對(duì)付的挑戰(zhàn)，那么，血液就會(huì)流向你的心臟和大腦，你就會(huì)經(jīng)歷到短暫但讓人精力充沛的皮質(zhì)醇增強(qiáng)。托那「放馬過(guò)來(lái)吧」習(xí)慣的福，你的端粒就會(huì)好好的。所以，這一切告訴我們什么?你的端粒好好的。你真的有力量可以改變你自己的端粒會(huì)發(fā)生什么事。
But our curiosity just got more and more intense,because we started to wonder,what about factors outside our own skin?Could they impact our telomere maintenance as well?You know, we humans are intensely social beings.Was it even possible that our telomeres were social as well?And the results have been startling.As early as childhood,emotional neglect, exposure to violence,bullying and racismall impact your telomeres,and the effects are long-term.Can you imagine the impact on childrenof living years in a war zone?People who can’t trust their neighborsand who don’t feel safe in their neighborhoodsconsistently have shorter telomeres.So your home address matters for telomeres as well.On the flip side,tight-knit communities,being in a marriage long-term,and lifelong friendships, even,all improve telomere maintenance.
但我們的好奇心變得越來(lái)越強(qiáng)烈，因?yàn)槲覀冮_(kāi)始納悶，我們身外的因素如何呢?它們能否影響我們的端粒維護(hù)呢?要知道，我們?nèi)祟?lèi)是極為社交的動(dòng)物。有沒(méi)有可能我們的端粒也很社交呢?而結(jié)果十分驚人。早至孩童時(shí)期，情緒忽視、接觸暴力、霸凌、及種族主義，都會(huì)影響你的端粒，且影響是長(zhǎng)期的。你們能想像在戰(zhàn)區(qū)內(nèi)的孩子，壽命會(huì)受到什么樣的影響?無(wú)法信任鄰居的人，在鄰坊中沒(méi)有安全感的人，很一致地，都有比較短的端粒。所以你住哪里，對(duì)于端粒也很重要。反過(guò)來(lái)說(shuō)，緊密連結(jié)的社區(qū)、長(zhǎng)期的婚姻、甚至一生的友誼，都能改善端粒的維護(hù)。
So what is all this telling us?It’s telling us that I have the power to impact my own telomeres,and I also have the power to impact yours.Telomere science has told us just how interconnected we all are.
所以，這一切告訴我們什么?它告訴我們，我有力量可以影響我自己的端粒，我也有力量可以影響你的端粒。端?？茖W(xué)告訴我們，我們是多么緊密連結(jié)在一起。
But I’m still curious.I do wonderwhat legacy all of uswill leave for the next generation?Will we investin the next young woman or manpeering through a microscope at the next little critter,the next bit of pond scum,curious about a question we don’t even know today is a question?It could be a great question that could impact all the world.And maybe, maybe you’re curious about you.Now that you know how to protect your telomeres,are you curious what are you going to dowith all those decades of brimming good health?And now that you know you could impact the telomeres of others,are you curioushow will you make a difference?And now that you know the power of curiosity to change the world,how will you make sure that the world invests in curiosityfor the sake of the generations that will come after us?
但我仍然好奇。我確實(shí)納悶，我們所有人會(huì)留給下一代什么遺產(chǎn)?我們是否會(huì)投資給接下來(lái)的年輕男、女，透過(guò)顯微鏡盯著下一個(gè)小生物、下一坨池塘浮渣，對(duì)我們現(xiàn)今仍未知的問(wèn)題感到好奇?那可能是個(gè)好問(wèn)題，能夠影響全世界。也許你對(duì)你自己很好奇?，F(xiàn)在你知道如何保護(hù)你的端粒了，你是否會(huì)好奇，未來(lái)數(shù)十年你將會(huì)做些什么來(lái)維持好健康?現(xiàn)在你知道你能夠影響他人的端粒了，你是否會(huì)好奇，你將會(huì)如何造成不同?現(xiàn)在你知道好奇的力量可以改變世界了，你要如何確保世界會(huì)為了我們之后的世代而投資在好奇心上?
Thank you.
謝謝。
(Applause)
(掌聲)
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